The Virtual
Human Platform

Safety assessment of chemicals and pharmaceuticals using human data-driven tools and case studies.

Case Studies

See how tools, methods and data combine to answer regulatory questions.

3 case studies

Tools

Select an in silico tool to streamline your safety assessment.

50 tools

Methods

Select an in vitro method to perform your safety assessment.

18 methods

Data

Find the (meta)data you need for tools and workflows.

14 datasets

Virtual Human Platform

A digital infrastructure for animal-free safety assessment.

The Virtual Human Platform (VHP) is a digital infrastructure that supports human-relevant risk assessment of chemicals and pharmaceuticals. By integrating human-derived data, advanced in vitro models, and computational tools, the VHP enables transparent, reproducible and mechanistically informed safety assessment moving beyond traditional animal testing.

Through structured, interactive workflows and a user-friendly interface, the platform tackles real-world regulatory questions ('case studies') by connecting tools, methods and data.

Safety Assessment Workflow

The Virtual Human Platform uses a generic safety assessment workflow as a five-step process to collect information critical for risk characterisation.

Regulatory question

Risk Characterisation

Chemical Characteristics and Hazard identification

Case studies

On the platform, three human relevant case studies are used as demonstrators:

Medication induced kidney toxicity, addressing disease state.
Neurodegeneration following lifelong pesticide exposure, addressing life course exposure.
Disruption of thyroid hormone mediated brain development due to chemical exposure, addressing sex and age specific differences.

These case studies show how multiple New Approach Methodologies (NAMs) can be combined to address regulatory challenges and illustrate practices concerning data, model assumptions, and interpretation.

Learn more about VHP4Safety, the project behind the VHP

Developed in co-creation with academic, industrial, regulatory, and societal partners, the VHP supports the transition to animal-free, human-relevant safety assessment. We invite all stakeholders to explore, contribute, and help shape the future of risk assessment with us.

Project

Training

Impact